Rapid-acting Antidepressants: New treatments, New Hope, and New Insights Into the Brain-Presentation Slides

Presentation Slides

Pdf Summary

The document discusses the topic of rapid-acting antidepressants, specifically focusing on ketamine as a potential treatment option. The author highlights the limitations of traditional antidepressants, including their low effectiveness, slow onset of action, and high relapse rates. The document also mentions the Emerging Topics Webinar Series offered by the American Psychiatric Association to stay updated on relevant topics in psychiatry. The author provides details on how to participate in the Q&A session during the webinar. <br /><br />Various disclosures related to the presenter, including sources of research support, consulting relationships, stock equity, patents, and paid editorial relationships, are listed. Collaboration and support from other researchers and institutions are acknowledged as well. <br /><br />The document discusses the problem with currently available antidepressants, citing their limited effectiveness, slow onset of action, and high relapse rates. The potential use of ketamine as a rapid-acting antidepressant is explored, and the author provides research evidence on its efficacy in treating depression, reducing suicidal ideation, and protecting against relapse. The document also discusses the safety of ketamine in long-term treatment and the increasing recreational use of ketamine. <br /><br />The effects of ketamine on glutamatergic and cortico-limbic circuits in the brain are described, along with its impact on gene expression and synaptic growth. The document also mentions the use of ketamine in treating other disorders such as PTSD, bipolar depression, and borderline personality disorder, among others. The potential mechanisms of action of ketamine and the role of behavioral interventions in enhancing its efficacy are discussed. The document concludes by emphasizing the need for further research and the potential for new treatments in the future.

Keywords

rapid-acting antidepressants

ketamine

traditional antidepressants

effectiveness

onset of action

relapse rates

Emerging Topics Webinar Series

Q&A session

ketamine safety

mechanisms of action