Rapid-acting Antidepressants: New treatments, New Hope, and New Insights Into the Brain
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Expires on Apr 11, 2026
Member: $50.00
Non-Member: $50.00
Medical Student: $0.00
Resident Fellow Member: $0.00
Credit Offered
1.5 CME Credits
1.5 COP Credits

This webinar will describe the path that led to the identification of the rapid antidepressant effects of ketamine. It will then describe its applications in clinical practice. The presentation will then describe emerging insights into the biology contributing to its distinctive clinical profile. Building on these insights, it will suggest some strategies that may enhance its clinical impact.


Enduring webinar

Learning Objectives

  • To provide insights into the clinical application of ketamine and Esketamine to “treatment-resistant” depression and depression in the context of increased suicide risk.
  • To shed light on emerging insights into the biology of depression and how this biology intersects with the impact of ketamine exposure on the brain.
  • To suggest psychotherapeutic and pharmacologic strategies that may enhance the impact of ketamine.


  • 1 hours of content
  • 30 minutes of Q and A

Target Audience

Counselor, Pharmacist, Psychiatrist, Psychologist, Physician (non-psychiatrist), Physician Assistant, Nurse/Nurse Practitioner, Social Worker, Peer Specialist/Peer Support

Estimate Time to Complete

Estimated Duration: 1.5 hour
Program Start Date: April 11, 2023
Program End Date: April 11, 2026

How to Earn Credit

After evaluating the program, participants will be provided with an opportunity to claim hours of participation and print an official CME certificate (physicians) or certificate of participation (non-physicians) showing the event date and hours earned.

Continuing Education Credit

In support of improving patient care, the American Psychiatric Association is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


The APA designates this enduring activity for a maximum of 1.5 AMA PRA Category 1 Credit ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Faculty and Planner Disclosures

The American Psychiatric Association adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Medical Education. Any individuals in a position to control the content of a CME activity — including faculty, planners, reviewers or others — are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.


  • John Krystal, MD, Professor of Translational Research and Professor of Psychiatry, Yale, has no relevant financial relationships to disclose.


  • Vishal Madaan, MD, Chief of Education, APA, has no relevant financial relationships to disclose.

Accessibility for Participants with Disabilities

The American Psychiatric Association is committed to ensuring accessibility of its website to people with disabilities. Please contact the American Psychiatric Association at 202-559-3900, if you require assistance seven (7) business days prior to the start of a live webinar.

Technical Requirements

This internet-based CME activity is best experienced using any of the following:

  • The latest and 2nd latest public versions of Google Chrome, Mozilla Firefox, or Safari
  • Internet Explorer 11+

This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Acrobat Reader, Microsoft PowerPoint, and Windows Media Player.

Optimal System Configuration:

  • Browser: Google Chrome (latest and 2nd latest version), Safari (latest and 2nd latest version), Internet Explorer 11.0+, Firefox (latest and 2nd latest version), or Microsoft Edge (latest and 2nd latest version)
  • Operating System: Windows versions 8.1+, Mac OS X 10.5 (Leopard) +, Android (latest and 2nd latest version), or iOS/iPad OS (latest and 2nd latest version)
  • Internet Connection: 1 Mbps or higher

Minimum Requirements:

  • Windows PC: Windows 8.1 or higher; 1 GB (for 32-bit)/2 GB (for 64-bit) or higher RAM; Microsoft DirectX 9 graphics device with WDDM driver; audio playback with speakers for programs with video content
  • Macintosh: Mac OS X 10.5 or higher with latest updates installed; Intel, PowerPC G5, or PowerPC G4 (867MHz or faster) processor; 512 MB or higher RAM; audio playback with speakers for programs with video content

For assistance: Contact educme@psych.org for questions about this activity

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