This course updates results in the ongoing International Study to Predict Optimized Treatment in Depression (iSPOT-D) that aims to identify practical, pretreatment measures to help select among three commonly prescribed antidepressants: escitalopram, sertraline or venlafaxine-XR. iSPOT-D mirrors routine practice while employing standardized pretreatment and post-treatment clinical and biological assessments in an 8 week randomized, 22 site acute treatment trial with up to a 44 week follow up.Specific allelic variation for MDR-1 predicts likelihood of remission in subgroups of subjects. Pretreatment behavioral measures of emotional identification, decision speed, attention and working memory were significant predictors of remission, independent of symptom severity. Further, interactions among performance on cognitive and emotional measures and genetic variation predicted outcome. A corresponding profile of limbic hyper-reactivity to emotional stimuli and frontal hypo-activity to cognitive and emotional tasks was revealed by functional neuroimaging.
**This content was captured at the 2014 APA Annual Meeting
- General Member - $22.50
- Resident-Fellow Member - Free
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Residents/Fellows and Psychiatrists
Participants who wish to earn AMA PRA Category 1 Credit ™ or a certificate of participation may do so by completing all sections of the course including the evaluation. A multiple choice quiz is provided based on the content. A passing score of 60% must be achieved. Retakes are available for the test. After evaluating the program, course participants will be provided with an opportunity to claim hours of participation and print an official CME certificate showing the date of completion and hours earned.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The APA designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
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