Objective: Although both pediatric and adult patients with anxiety disorders exhibit similar neural responding to threats, age-related differences have been found in some functional MRI (fMRI) studies. To reconcile disparate findings, the authors compared brain function in youths and adults with and without anxiety disorders while rating fear and memory of ambiguous threats.
Methods: Two hundred medication-free individuals ages 8–50 were assessed, including 93 participants with an anxiety disorder. Participants underwent discriminative threat conditioning and extinction in the clinic. Approximately 3 weeks later, they completed an fMRI paradigm involving extinction recall, in which they rated their levels of fear evoked by, and their explicit memory for, morph stimuli with varying degrees of similarity to the extinguished threat cues.
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The participant will recognize age differences in the neural correlates of anxiety disorders.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Duration: 1 hour
Begin Date: May 1, 2020
End Date: April 30, 2022
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Title: Age Differences in the Neural Correlates of Anxiety Disorders: An fMRI Study of Response to Learned Threat
Authors: Andrea L. Gold, Ph.D., Rany Abend, Ph.D., Jennifer C. Britton, Ph.D., Brigid Behrens, B.S., Madeline Farber, M.S., Emily Ronkin, M.A., Gang Chen, Ph.D., Ellen Leibenluft, M.D., Daniel S. Pine, M.D.
Affiliations: Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, and Pediatric Anxiety Research Center, Bradley Hospital, Riverside, R.I. (A.L.G.); Emotion and Development Branch, NIMH, Bethesda, Md. (R.A., B.B., M.F., E.R., E.L., D.S.P.); Department of Psychology, University of Miami, Coral Gables, Fla. (J.C.B.); Scientific and Statistical Computing Core, NIMH, Bethesda, Md. (G.C.).
Disclosures: The authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
Ned H. Kalin, M.D. (Editor-in-Chief, AJP); Carolyn Rodriguez, M.D., Ph.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP); Michael A. Pogachar (Online Content Manager, Journals). Dr. Kalin has served as a consultant to the Board of Scientific Advisors, the Pritzker Neuropsychiatric Disorders Research Consortium, and the Skyland Trail Advisory Board and as Councilor, Society of Biological Psychiatry. Dr. Rodriguez has served as a consultant to Allergan, Blackthorn, Epiodyne, and Rugen. Mr. Roy and Mr. Pogachar report no financial relationships with commercial interests.
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