Objective: Previous studies suggest that prenatal immune challenges may elevate the risk of schizophrenia and related psychoses in offspring, yet there has been limited research focused on maternal bacterial infection. The authors hypothesized that maternal bacterial infection during pregnancy increases offspring risk of psychotic disorders in adulthood, and that the magnitude of this association varies as a function of severity of infectious exposure and offspring sex.
Methods: The authors analyzed prospectively collected data from 15,421 pregnancies among women enrolled between 1959 and 1966 at two study sites through the Collaborative Perinatal Project. The sample included 116 offspring with confirmed psychotic disorders. The authors estimated associations between maternal bacterial infection during pregnancy and psychosis risk over the subsequent 40 years, stratified by offspring sex and presence of reported parental mental illness, with adjustment for covariates.
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The participant will identify key risk factors and methodological considerations involved in the etiologic relationship between prenatal bacterial infection and psychotic disorders in adulthood.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Duration: 1 hour
Begin Date: January 1, 2020
End Date: December 31, 2021
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Title: Maternal Bacterial Infection During Pregnancy and Offspring Risk of Psychotic Disorders: Variation by Severity of Infection and Offspring Sex
Authors: Younga H. Lee, Ph.D., Sara Cherkerzian, Sc.D., Larry J. Seidman, Ph.D., George D. Papandonatos, Ph.D., David A. Savitz, Ph.D., Ming T. Tsuang, M.D., Ph.D., Jill M. Goldstein, Ph.D., Stephen L. Buka, Sc.D.
Affiliations: Department of Epidemiology, Brown University, Providence, R.I. (Y.H.L., D.A.S., S.L.B.); Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston (S.C.); Department of Medicine, Harvard Medical School, Boston (S.C., J.M.G.); Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston (L.J.S.); Department of Psychiatry, Massachusetts General Hospital, Boston (L.J.S., J.M.G.); Department of Psychiatry, Harvard Medical School, Boston (L.J.S., J.M.G.); Division of Women’s Health, Department of Medicine, Brigham and Women’s Hospital, Boston (J.M.G.); Center for Statistical Sciences, Brown University, Providence, R.I. (G.D.P.); and Department of Psychiatry, University of California San Diego, La Jolla (M.T.T.).
Disclosures: Dr. Goldstein has served as a consultant for Cala Health. The other authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
Ned H. Kalin, M.D. (Editor-in-Chief, AJP); Carolyn Rodriguez, M.D., Ph.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP); Michael A. Pogachar (Online Content Manager, Journals). Dr. Kalin has served as a consultant to the Board of Scientific Advisors, the Pritzker Neuropsychiatric Disorders Research Consortium, and the Skyland Trail Advisory Board and as Councilor, Society of Biological Psychiatry. Dr. Rodriguez has served as a consultant to Allergan, Blackthorn, Epiodyne, and Rugen. Mr. Roy and Mr. Pogachar report no financial relationships with commercial interests.
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