Objective: High comorbidity among psychiatric disorders suggests that they may share underlying neurobiological deficits. Abnormalities in cortical thickness and volume have been demonstrated in clinical samples of adults, but less is known when these structural differences emerge in youths. The purpose of this study was to examine the association between dimensions of psychopathology and brain structure.
Methods: The authors studied 1,394 youths who underwent brain imaging as part of the Philadelphia Neurodevelopmental Cohort. Dimensions of psychopathology were constructed using a bifactor model of symptoms. Cortical thickness and volume were quantified using high-resolution 3-T MRI. Structural covariance networks were derived using nonnegative matrix factorization and analyzed using generalized additive models with penalized splines to capture both linear and nonlinear age-related effects.
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The participant will differentiate how perturbations in brain development may be correlated to various dimensions of psychopathology.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Duration: 1 hour
Begin Date: December 1, 2019
End Date: November 30, 2021
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Title: Evidence for Dissociable Linkage of Dimensions of Psychopathology to Brain Structure in Youths
Authors: Antonia N. Kaczkurkin, Ph.D., Sophia Seonyeong Park, M.A., Aristeidis Sotiras, Ph.D., Tyler M. Moore, Ph.D., Monica E. Calkins, Ph.D., Matthew Cieslak, Ph.D., Adon F.G. Rosen, B.S., Rastko Ciric, B.A., Cedric Huchuan Xia, B.S., Zaixu Cui, Ph.D., Anup Sharma, M.D., Ph.D., Daniel H. Wolf, M.D., Ph.D., Kosha Ruparel, M.S.E., Daniel S. Pine, M.D., Russell T. Shinohara, Ph.D., David R. Roalf, Ph.D., Ruben C. Gur, Ph.D., Christos Davatzikos, Ph.D., Raquel E. Gur, M.D., Ph.D., Theodore D. Satterthwaite, M.D.
Affiliations: The Department of Psychiatry (A.N.K., T.M.M., M.E.C., M.C., A.F.G.R., R.C., C.H.X., Z.C., A.S., D.H.W., K.R., D.R.R., R.C.G., R.E.G., T.D.S.) and the Department of Radiology (A.S., R.C.G., C.D., R.E.G.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (S.S.P.); the Department of Radiology, Washington University, St. Louis (A.S.); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (D.S.P.); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (R.T.S.); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C.G.).
Disclosures: Dr. Sotiras is a stockholder in TheraPanacea. Dr. Shinohara has received legal consulting and advisory board income from Genentech/Roche; he has received compensation for editorial and review duties from the American Medical Association, NIH, and Research Square; and he has received grant support from the National Multiple Sclerosis Society, NIH, and the Race to Erase MS. The other authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
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