Objective: Sensory overresponsivity (SOR), an atypical negative reaction to sensory stimuli, is highly prevalent in autism spectrum disorder (ASD). Previous work has related SOR to increased brain response in sensory-limbic regions. This study investigated where these atypical responses fall in three fundamental stages of sensory processing: arousal (i.e., initial response), habituation (i.e., change in response over time), and generalization of response to novel stimuli. Different areas of atypical response would require distinct intervention approaches.
Methods: Functional MRI was used to examine these patterns of neural habituation to two sets of similar mildly aversive auditory and tactile stimuli in 42 high-functioning children and adolescents with ASD (21 with high levels of SOR and 21 with low levels of SOR) and 27 age-matched typically developing youths (ages 8–17). The relationship between SOR and change in amygdala-prefrontal functional connectivity across the sensory stimulation was also examined.
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The participant will explain how sensory overresponsivity in autism affects the neurobiology of arousal, habituation, and response generalization.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Duration: 1 hour
Begin Date: December 1, 2019
End Date: November 30, 2021
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Title: Distinct Patterns of Neural Habituation and Generalization in Children and Adolescents With Autism With Low and High Sensory Overresponsivity
Authors: Shulamite A. Green, Ph.D., Leanna Hernandez, Ph.D., Katherine E. Lawrence, B.A., Janelle Liu, B.A., Tawny Tsang, Ph.D., Jillian Yeargin, M.A., Kaitlin Cummings, B.A., Elizabeth Laugeson, Psy.D., Mirella Dapretto, Ph.D., Susan Y. Bookheimer, Ph.D.
Affiliations: The Jane and Terry Semel Institute of Neuroscience and Human Behavior, Psychiatry and Biobehavioral Sciences, University of California Los Angeles (S.A.G., L.H., K.E.L., J.L., J.Y., K.C., E.L., M.D., S.Y.B.); Yale Child Study Center, Yale University, New Haven, Conn. (T.T.); and the Help Group–UCLA Autism Research Alliance, Los Angeles (E.L.).
Disclosures: Dr. Laugeson receives royalties from Wiley and Taylor & Francis. The other authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
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