Activity Preview


Preclinical Development of Ketamine and the Metabolite 2R-6R-Hydroxynorketamine for Depression and Other Disorders

Activity Type:

  • On Demand

Release Date: 10/28/2019

Expiration Date: 10/28/2022

  • AMA PRA Category 1: 1
  • Participation: 1



Preclinical studies indicate that 2R-6R-Hydroxynorketamine is a putative fast-acting antidepressant candidate. This session, recorded from the 2019 Amygdala, Stress and PTSD Conference at the Uniformed Services University, will outline the potential benefits and negatives of using ketamine in the treatment of mental health disorders.

The Amgydala, Stress and PTSD Conference at the Uniformed Services University brings together scientists and clinicians working towards solving the biological basis of stress, fear, and posttraumatic stress disorder. Sessions at this conference promote awareness of complementary areas that relate to trauma and the amygdala.


FREE - $0

Funding for this initiative was made possible (in part) by Grant No. 1H79SM080818-01 from SAMHSA. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. (Effective January 31, 2020)

Learning Objectives

  • Characterize the state of research on developing rapid-acting antidepressants for treatment-resistant depression
  • Critique the potential benefits of using ketamine in the treatment of mental health disorders
  • Assess the potential negatives of using ketamine in the treatment of mental health disorders

Target Audience


Estimated Time to Complete

Estimated Duration: 60 minutes
Begin Date: October 28, 2019
End Date: October 28, 2022

How to Earn Credit

Participants who wish to earn AMA PRA Category 1 Credit ™ or a certificate of participation may do so by completing all sections of the course including the evaluation. A multiple choice quiz is provided based on the content. A passing score of 100% must be achieved. Retakes are available for the test. After evaluating the program, course participants will be provided with an opportunity to claim hours of participation and print an official CME certificate (physicians) or certificate of participation (non-physicians) showing the completion date and hours earned. 

Continuing Education Credit

The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

The APA designates this enduring CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Faculty and Planner Disclosures


  • Irwin Lucki, PhD, Professor and Chair, Department of Pharmacology, Uniformed Services University. Disclosures: Consultant - Alkermes

Program Planners

  • Eric G. Meyer, M.D., Associate Clerkship Director and Assistant Professor, Uniformed Services University of the Health Sciences. Reports no financial relationships with commercial interests. 
  • Lisa Diener, Director of Membership and Member Engagement, American Psychiatric Association. Reports no financial relationships with commercial interests.

Accessibility for Participants with Disabilities

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Hardware/Software Requirements

This internet-based CME activity is best experienced using Internet Explorer 8+, Mozilla Firefox 3+, Safari 4+. This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Adobe Acrobat, Microsoft PowerPoint, and Windows Media Player.

Optimal System Configuration:

  • Flash Player: Adobe Flash Player 10.3+ 
  • Browser: Firefox (latest version), Internet Explorer 8.0+, Safari 7.0+, Microsoft Edge (latest version) or Google Chrome (latest version)
  • Operating System: Windows XP+ or Mac OS X 10.4+ 
  • Internet Connection: 1 Mbps or higher

Minimum Requirements:

  • Windows PC: 500-MHz Pentium II; Windows XP or higher; 128 MB RAM; Video Card at least 64MB of video memory; Macromedia Flash Player 10.3 or higher; Sound Card at least 16-bit; audio playback with speakers for programs with video content
  • Macintosh:Mac OS X 10.4+ or higher with latest updates installed; 1.83MHz Intel Core Duo or faster; RAM: 128MB or more; Video Card: at least 64MB of video memory; Sound Card: at least 16-bit; audio playback with speakers for programs with video content

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