Objective: Schizophrenia is associated with a marked cognitive impairment that is widely believed to remain stable after illness onset. Yet, to date, 10-year prospective studies of cognitive functioning following the first episode with good methodology are rare. The authors examined whether schizophrenia patients experience cognitive decline after the first episode, whether this decline is generalized or confined to individual neuropsychological functions, and whether decline is specific to schizophrenia.
Methods: Participants were from a population-based case-control study of patients with first-episode psychosis who were followed prospectively up to 10 years after first admission. A neuropsychological battery was administered at index presentation and at follow-up to patients with a diagnosis of schizophrenia (N=65) or other psychoses (N=41) as well as to healthy comparison subjects (N=103).
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The participant will recognize the cognitive changes observed over a long follow-up period after a first episode of psychosis both in schizophrenia and in other psychosis.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Duration: 1 hour
Begin Date: October 1, 2019
End Date: September 30, 2021
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Title: Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode
Authors: Jolanta Zanelli, Ph.D., Josephine Mollon, Ph.D., Sven Sandin, Ph.D., Craig Morgan, Ph.D., Paola Dazzan, M.D., Ph.D., Izabela Pilecka, Ph.D., Tiago Reis Marques, M.D., Ph.D., Anthony S. David, M.D., Kevin Morgan, Ph.D., Paul Fearon, M.D., Ph.D., Gillian A. Doody, M.D., Peter B. Jones, M.D., Ph.D., Robin M. Murray, F.R.S., Abraham Reichenberg, Ph.D.
Affiliations: The Department of Psychosis Studies (J.Z., P.D., I.P., T.R.M., A.S.D., R.M.M., A.R.) and the Department of Psychology (I.P.), Institute of Psychiatry, Psychology, and Neuroscience, King’s College London; the Department of Psychiatry, Harvard Medical School, Boston (J.M.); the Department of Psychiatry (S.S., A.R.), the Department of Environmental Medicine and Public Health, and the Friedman Brain Institute (A.R.), Icahn School of Medicine at Mount Sinai, New York; the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (S.S.); the Centre for Public Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London (C.M.); the Department of Psychology, University of Westminster, London (K.M.); the Department of Psychiatry, Trinity College, Dublin (P.F.); the Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, U.K. (G.A.D.); and the Department of Psychiatry, University of Cambridge, Cambridge, U.K., and the Institute of Mental Health, University College London (P.B.J.).
Disclosures: Dr. Reis Marques has received investigator-initiated research funding from or participated in advisory or speaker meetings organized by Angelini, Autifony, Biogen, Janssen, Lundbeck, and Roche. Dr. Jones has served as a consultant for Bristol-Myers Squibb, Eli Lilly, and Otsuka and as a member of scientific advisory boards for Johnson & Johnson, Lundbeck, and Ricordati. Dr. Murray has received speaking honoraria from Janssen, Lundbeck, Otsuka, and Sunovion. The other authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
Ned H. Kalin, M.D. (Editor-in-Chief, AJP); Carolyn Rodriguez, M.D., Ph.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP); Michael A. Pogachar (Online Content Manager, Journals). Dr. Kalin has served as a consultant to the Board of Scientific Advisors, the Pritzker Neuropsychiatric Disorders Research Consortium, and the Skyland Trail Advisory Board and as Councilor, Society of Biological Psychiatry. Dr. Rodriguez has served as a consultant to Allergan, Blackthorn, Epiodyne, and Rugen. Mr. Roy and Mr. Pogachar report no financial relationships with commercial interests.
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