Fentanyl has been the leading cause of opioid overdoses during the last couple of years, and these overdoses are not prevented by methdone, buprenorphine or naltrexone treatment. However, a vaccine against fentanyl has been able to block fentanyl's analgesic, reinforcing and respiratory effects in animal models. This vaccine is moving forward FDA approval to be tested in humans. This presentation will discuss the mechanism of acting for fentanyl vaccines in preventing overdoses and abuse through the production of anti-fentanyl antibodies.
Funding for this initiative was made possible (in part) by grant no. 5U79TI026556-03 from SAMHSA. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. pcssnow.org
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- Identify the extent and greatest geographic concentration of fentanyl overdoses and abuse in the current USA opioid epidemic.
- Define how and why current treatments with naltrexone, methadone and buprenorphine are ineffective for fentanyl abuse.
- Identify the mechanism of acting for fentanyl vaccines in preventing overdoses and abuse through the production of anti-fentanyl antibodies.
Physicians who have a waiver to treat opioid use disorder in an office-based setting and other interested clinicians.
Estimated Time to Complete
Estimated Duration: 1 hour
Begin Date: May 28, 2019
End Date: May 28, 2022
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Faculty and Planner Disclosures
- Thomas Kosten, M.D., Director, Division of Alcohol and Addiction Psychiatry, Baylor College of Medicine. Disclosure: Consultant - Alkermes US World Pharma.
- Fang Yang, M.D., Addiction Psychiatry Fellow, Baylor College of Medicine. Reports no financial relationships with commercial interests.
- John A. Renner, Jr., M.D., Professor of Psychiatry, Boston University School of Medicine; Director, Addiction Psychiatry Residency Training, Boston University Medical Center and VA Boston Healthcare System. Disclosure: Stockholder: Johnson & Johnson and General Electric.
- Eunice Maize, American Psychiatric Association. Reports no finanical relationships with commercial interests
- Rachel Trusty, American Psychiatric Association. Reports no finanical relationships with commercial interests
- Tristan Gorrindo, M.D., American Psychiatric Association. Reports no finanical relationships with commercial interests
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