Objective: Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with diverse associated risk factors and comorbidities. In this study, the authors sought to understand ADHD from a dimensional perspective and to identify neuroanatomical correlates of traits and behaviors that span diagnostic criteria.
Method: Multimodal neuroimaging data and multi-informant cognitive and clinical data were collected in a densely phenotyped pediatric cohort (N=160; 70 with ADHD; age range, 9–12 years). Multivariate analysis identified associations between clinical and cognitive factors and multimodal neuroimaging markers (across tissue volume, cortical thickness, cortical area, and white matter microstructure). The resulting imaging markers were validated in an independent cohort (N=231; 132 with ADHD; age range, 7–18 years).
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The participant will diagram how the presentation of attention deficit hyperactivity disorder may stem from a number of clinical, developmental, or cognitive variables that have their own unique neurobiological foundations.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Duration: 1 hour
Begin Date: January 1, 2019
End Date: December 31, 2020
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Title: Multimodal Structural Neuroimaging Markers of Brain Development and ADHD Symptoms
Authors: Gareth Ball, Ph.D., Charles B. Malpas, Ph.D., Sila Genc, M.Sc., Daryl Efron, M.D., F.R.A.C.P., Emma Sciberras, D.Psych., Vicki Anderson, Ph.D., Jan M. Nicholson, Ph.D., Timothy J. Silk, Ph.D.
Affiliations: Developmental Imaging, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Australia (G.B., C.B.M., S.G., V.A., T.J.S.); Population Health, Murdoch Children’s Research Institute, Melbourne (D.E., E.S., J.M.N.); the Royal Children’s Hospital, Melbourne (D.E., V.A., T.J.S.); the Department of Paediatrics, University of Melbourne, Melbourne (S.G., D.E., E.S.); the Judith Lumley Centre, La Trobe University, Melbourne (J.M.N.); the School of Psychology, Deakin University, Geelong, Australia (E.S., T.J.S.); and the Melbourne School of Psychological Sciences, University of Melbourne, Melbourne (C.B.M.).
Disclosures: The authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
Ned H. Kalin, M.D. (Editor-in-Chief, AJP); Michael D. Roy (Editorial Director, AJP); Michael A. Pogachar (Online Content Manager, Journals).
Dr. Kalin has received research support from NIH and NIMH; has served as a consultant for APA, CME Outfitters, the Pritzker Neuropsychiatric Disorders Research Consortium, the Skyland Trail Advisory Board, and TC MSO; owns stock in Celgene and Seattle Genetics; and received honoraria from Elsevier as co-editor of the journal Psychoneuroendocrinology. Mr. Roy and Mr. Pogachar report no financial relationships with commercial interests.
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