Objective: Children of mothers with severe mental illness are at significantly increased risk of developing intellectual disability. Obstetric complications are also implicated in the risk for intellectual disability. Moreover, children of mothers with severe mental illness are more likely to be exposed to obstetric complications. The purpose of this study was to examine the independent and joint contributions of familial severe mental illness and obstetric complications to the risk of intellectual disability.
Method: Record linkage across Western Australian whole-population psychiatric, inpatient, birth, and midwives’ registers identified 15,351 children born between 1980 and 2001 to mothers with severe mental illness and 449,229 children born to mothers with no mental illness. Multivariable models were adjusted for paternal psychiatric status, parental intellectual disability, and other family and sociodemographic covariates.
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The participant will summarize the separate contributions to risk of intellectual disability in children arising from exposure to maternal severe mental illness and exposure to obstetric complications.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Duration: 1 hour
Begin Date: December 1, 2018
End Date: November 30, 2020
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Title: Intellectual Disability and Psychotic Disorders in Children: Association With Maternal Severe Mental Illness and Exposure to Obstetric Complications in a Whole-Population Cohort
Authors: Patsy Di Prinzio, M.Biostat., Vera A. Morgan, M.Soc.Sc., Ph.D., Jonas Björk, Ph.D., Maxine Croft, Ph.D., Ashleigh Lin, Ph.D., Assen Jablensky, M.D., D.M.Sc., Thomas F. McNeil, Ph.D.
Affiliations: From the Division of Psychiatry, Neuropsychiatric Epidemiology Research Unit, the University of Western Australia Medical School, Perth, Australia (P.D.P., V.A.M., M.C., A.L., T.F.M.N.); the Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden (J.B.); the Telethon Kids Institute, University of Western Australia, Perth (A.L.); and the Division of Psychiatry, Centre for Research in Clinical Neurosciences, University of Western Australia Medical School, Perth (V.A.M., A.J.).
Disclosures: The authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
Robert Freedman, M.D. (Editor-in-Chief, AJP); Susan K. Schultz, M.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP); Michael A. Pogachar (Online Content Manager, Journals).
Dr. Schultz has received research support from the Alzheimer’s Disease Cooperative Study for projects conducted in partnership with Toyama Chemical Company and in partnership with Eli Lilly and Company. Dr. Freedman, Mr. Roy, and Mr. Pogachar report no financial relationships with commercial interests.
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