Objective: The purpose of this study was to assess the relative risk of suicide attempt and suicide in users of hormonal contraception.
Method: The authors assessed associations between hormonal contraceptive use and suicide attempt and suicide in a nationwide prospective cohort study of all women in Denmark who had no psychiatric diagnoses, antidepressant use, or hormonal contraceptive use before age 15 and who turned 15 during the study period, which extended from 1996 through 2013. Nationwide registers provided individually updated information about use of hormonal contraception, suicide attempt, suicide, and potential confounding variables. Psychiatric diagnoses or antidepressant use during the study period were considered potential mediators between hormonal contraceptive use and risk of suicide attempt. Adjusted hazard ratios for suicide attempt and suicide were estimated for users of hormonal contraception as compared with those who never used hormonal contraception.
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The participant will classify the frequency of suicide attempts and suicides among young women and recognize the association between these conditions and use of hormonal contraception.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Estimated Time to Complete
Duration: 1 hour
Begin Date: April 1, 2018
End Date: March 31, 2020
How to Earn Credit
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Faculty and Planner Disclosures
Title: Association of Hormonal Contraception With Suicide Attempts and Suicides
Authors: Charlotte Wessel Skovlund, Ph.D., Lina Steinrud Mørch, Ph.D., Lars Vedel Kessing, D.M.Sc., Theis Lange, Ph.D., Øjvind Lidegaard, D.M.Sc.
Affiliations: From the Department of Gynecology and the Psychiatric Center Copenhagen, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (C.W.S., L.S.M., L.V.K., O.L.); the Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen (T.L.); and the Center for Statistical Science, Peking University, Beijing (T.L.).
Disclosures: Prof. Kessing has served as a consultant for AstraZeneca, Lundbeck, and Sunovion. Dr. Lange has served on a data safety monitoring committee for Novo Nordisk. Prof. Lidegaard has received speaking honoraria from Exeltis. The other authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
Robert Freedman, M.D. (Editor-in-Chief, AJP); Susan K. Schultz, M.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP); Michael A. Pogachar (Online Content Manager, Journals).
Dr. Schultz has received research support from the Alzheimer’s Disease Cooperative Study for projects conducted in partnership with Toyama Chemical Company and in partnership with Eli Lilly and Company. Dr. Freedman, Mr. Roy, and Mr. Pogachar report no financial relationships with commercial interests.
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