Cannabis has been used as a therapeutic agent for millennia and was part of the U.S. pharmacopeia until the 20th century. Recent progress in understanding neurobiology of the endocannabinoid signaling system has provided an improved scientific basis for examining the mechanisms of therapeutic action of the cannabinoids. A number of clinical trials have provided moderate to strong evidence that cannabis may be useful in the management of neuropathic pain, spasticity of multiple sclerosis, improving weight gain with patients with cachexia, and reducing nausea and vomiting. Newer research suggests the possibility that some cannabinoids may be promising in the treatment of certain forms of epilepsy, anxiety disorders and possibly schizophrenia. The challenges for the future will be how to standardize cannabis purity and dosage and deliver it in a form that is as well controlled as other medications. Additional promising areas include the development of novel molecules that in various ways modify the functioning of the endocannabinoid system. This presentation reviews the endocannabinoid system and discusses the potential benefits of cannabidiol.
**This content was captured at the 2017 APA Annual Meeting and may reference information from various sources and terminology from previous editions of the DSM.
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Free member registration for this course through the Course of the Month program ended on April 30, 2018.
- Explain the endocannabinoid system and exogenous cannabinoids
- Discuss the literature on the association between cannabinoids, specifically delta-9-tetrahydrocannabinol, and psychosis related outcomes
- Describe cannabidiol and its potential benefits
Estimated Time to Complete
Estimated Duration: 30 minutes
Begin Date: April 1, 2018
End Date: December 31, 2020
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Participants who wish to earn AMA PRA Category 1 Credit ™ or a certificate of participation may do so by completing all sections of the course including the evaluation. A multiple choice quiz is provided based on the content. A passing score of 100% must be achieved. Retakes are available for the test. After evaluating the program, course participants will be provided with an opportunity to claim hours of participation and print an official CME certificate (physicians) or certificate of participation (non-physicians) showing the completion date and hours earned.
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The APA designates this enduring CME activity for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Faculty and Planner Disclosures
- Mohini Ranganathan, M.D., Yale School of Medicine. Disclosures: (Employee) INSYS Therapeutic, Pfizer
- Tristan Gorrindo, M.D., Director of Education, American Psychiatric Association. Reports no financial relationships with commercial interests.
- Ricardo A. Juarez, M.S., Director, District Branch and International Relations, American Psychiatric Association. Reports no financial relationships with commercial interests.
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