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AJP CME: November 2017 - Copy Number Variation in Syndromic Forms of Psychiatric Illness: The Emerging Value of Clinical Genetic Testing in Psychiatry

Activity Type:

  • Journal CME

Release Date: 11/1/2017

Expiration Date: 10/31/2019

  • AMA PRA Category 1 Physician: 1
  • Participation: 1

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Abstract: Despite extensive efforts and recent major successes, the genetic architecture of psychiatric disorders has remained insufficiently understood to recommend genetic testing as part of the routine diagnostic evaluation in clinical psychiatry. With recent developments in advanced molecular genetic techniques and a considerable reduction in costs, there has been a dramatic improvement in our understanding of the genetic underpinnings of severe psychiatric disorders. The strong heritability of severe psychiatric disorders was initially suggested by high rates of concordance in studies of monozygotic twins as well as in adoption studies, especially in those involving monozygotic twins. Additionally, in large epidemiological studies, it has been repeatedly demonstrated that the risk of psychiatric illness is inversely proportional to the genetic distance from an affected relative.


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Educational Objective

The participant will assess an argument for the introduction of clinical genetic evaluations into routine psychiatric practice.

Target Audience

This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.

Estimated Time to Complete

Duration: 1 hour
Begin Date: November 1, 2017
End Date: October 31, 2019

How to Earn Credit

In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™).  A score of 60% or higher is required to receive credit.


The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Faculty and Planner Disclosures

Title: Copy Number Variation in Syndromic Forms of Psychiatric Illness: The Emerging Value of Clinical Genetic Testing in Psychiatry

Authors: Christian G. Bouwkamp, Ph.D., Anneke J.A. Kievit, M.D., Ph.D., Sander Markx, M.D., Joseph I. Friedman, M.D., Laura van Zutven, Ph.D., Rick van Minkelen, Ph.D., Terry Vrijenhoek, Ph.D., Bin Xu, Ph.D., Ineke Sterrenburg-van de Nieuwegiessen, M.D., Joris A. Veltman, Ph.D., Vincenzo Bonifati, M.D., Ph.D., Steven A. Kushner, M.D., Ph.D.

Affiliations: From the Department of Psychiatry and the Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), Rotterdam, the Netherlands (C.G.B., A.J.A.K., S.M., L.V.Z., R.V.M., V.B., S.A.K.); the Department of Psychiatry and the Center for Precision Neuropsychiatry, Columbia University, New York (S.M., B.X.); New York State Psychiatric Institute, New York (S.M., B.X.); the Departments of Psychiatry, Neuroscience, and Human Genetics, Mount Sinai School of Medicine, New York (J.I.F.); the Clinical Neuroscience Center, Pilgrim Psychiatric Center, West Brentwood, N.Y. (J.I.F.); the Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands (T.V.); Delta Psychiatric Center, Portugaal, the Netherlands (I.S.V.D.N.); the Department of Human Genetics, Donders Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (J.A.V.); and the Department of Clinical Genetics, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands (J.A.V.).

Disclosures: Dr. Bonifati has received research grants from the Erasmus MC, Rotterdam, the Stichting ParkinsonFonds (Netherlands), and ZonMw under the aegis of the EU Joint Programme–Neurodegenerative Disease Research; he has received compensation for serving as Section Editor of Current Neurology and Neuroscience Reports and Associate Editor of Parkinsonism and Related Disorders; he has received honoraria from the International Parkinson and Movement Disorder Society, Elsevier, Springer Science + Business Media, and LSP Life Sciences Fund. Dr. Kushner has received funding from ZonMw Vidi (grant 017.106.384) from the Netherlands Organization for Scientific Research (NWO), the Dutch Technology Foundation (the applied science division of NWO), and the Technology Program of the Ministry of Economic Affairs (Project 12197), as well as by the NeuroBasic PharmaPhenomics consortium and the Erasmus University Medical Center. The other authors report no financial relationships with commercial interests.

Discussion of unapproved or investigational use of products*: No.

*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.

Program Planners

Robert Freedman, M.D. (Editor-in-Chief, AJP); Susan K. Schultz, M.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP); Michael A. Pogachar (Online Content Manager, Journals).

Dr. Schultz has received research support from the Alzheimer’s Disease Cooperative Study for projects conducted in partnership with Toyama Chemical Company and in partnership with Eli Lilly and Company. Dr. Freedman, Mr. Roy, and Mr. Pogachar report no financial relationships with commercial interests.

Hardware/Software Requirements

This internet-based CME activity is best experienced using Internet Explorer 8+, Mozilla Firefox 3+, Safari 4+. This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Adobe Acrobat, Microsoft PowerPoint, and Windows Media Player.
Optimal System Configuration:
  • Flash Player: Adobe Flash Player 10.1+ 
  • Browser: Firefox 3+, Internet Explorer 8.0+, Safari 4.0+, or Google Chrome 7.0+ 
  • Operating System: Windows XP+ or Mac OS X 10.4+ 
  • Internet Connection: 1 Mbps or higher
  • Screen Resolution: 1024 x 768 pixels.

Minimum Requirements:

  • Windows PC:500-MHz Pentium II; Windows XP or higher; 128 MB RAM; Video Card at least 64MB of video memory; Sound Card at least 16-bit; Macromedia Flash Player 10 or higher, audio playback with speakers for programs with video content; Firefox 1.1+, Internet Explorer 7.0+, Safari 1.0+, Google Chrome, or Opera
  • Macintosh: Mac OS X 10.3 or higher with latest updates installed; 1.83MHz Intel Core Duo or faster; RAM: 128MB or more; Video Card: at least 64MB of video memory; Sound Card: at least 16-bit

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