Abstract: In order to better understand the management of cases such as Mr. A’s involving pharmacogenetic testing issues in psychiatry, it is important to have some understanding of the role of such test profiles in clinical cases. Medical genetics is defined as the study of how genes are identified and used for medical applications, including identification of disease or predilection for disease, and for tailoring treatment through targeted drug therapy. Pharmacogenomics, more specifically, is the study of how a person’s genome affects his or her response to certain medications. It must be mentioned that medications can be influenced by a multitude of other factors, including age, sex, ethnicity, liver and kidney function, concomitant medications, and so on. Pharmacogenetics seeks to identify specific genetic polymorphisms in or near the coding region of genes that encode protein structures with which a drug interacts. The identified genetic polymorphisms are then assessed for the putative role in the observed individual variability in the clinical profile of the drug, most notably the drug’s pattern of response and/or side effects.
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The participant will interpret evidence for and against the use of pharmacogenetic testing to justify its use in the treatment of mental disorders.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Estimated Time to Complete
Duration: 1 hour
Begin Date: October 1, 2017
End Date: September 30, 2019
How to Earn Credit
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Faculty and Planner Disclosures
Title: Misleading Guidance From Pharmacogenomic Testing
Authors: Tahir Rahman, M.D., David M. Ash, M.D., John Lauriello, M.D., Roshni Rawlani
Affiliations: From the Department of Psychiatry, University of Missouri School of Medicine, Columbia (T.R., D.M.A., J.L., R.R.).
Disclosures: Dr. Lauriello has served on an event monitoring board for a clinical trial through a contract with Janssen Pharmaceutica and the University of Missouri; he has served on advisory panels for Janssen, Otsuka, Reckitt Benckiser, Sunovion, and Teva; and he has overseen clinical research sites for Columbia University sponsored by Sunovion and for Florida Atlantic University sponsored by Otsuka. The other authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
Robert Freedman, M.D. (Editor-in-Chief, AJP); Susan K. Schultz, M.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP); Michael A. Pogachar (Online Content Manager, Journals).
Dr. Schultz has received research support from the Alzheimer’s Disease Cooperative Study for projects conducted in partnership with Toyama Chemical Company and in partnership with Eli Lilly and Company. Dr. Freedman, Mr. Roy, and Mr. Pogachar report no financial relationships with commercial interests.
Optimal System Configuration:
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