Objective: While the increased risk of psychopathology in the biological offspring of depressed parents has been widely replicated, the long-term outcome through their full age of risk is less known. The authors present a 30-year follow-up of biological offspring (mean age=47 years) of depressed (high-risk) and nondepressed (low-risk) parents.
Method: One hundred forty-seven offspring of moderately to severely depressed or nondepressed parents selected from the same community were followed for up to 30 years. Diagnostic assessments were conducted blind to parents’ clinical status. Final diagnoses were made by a blinded M.D. or Ph.D. evaluator.
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The participant will distinguish key differences in measures of depression, morbidity, and mortality between offspring of parents with and without depression who were followed for 30 years.
This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.
Duration: 1 hour
Begin Date: October 1, 2016
End Date: September 30, 2018
In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the quiz and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™). A score of 60% or higher is required to receive credit.
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Title: Offspring of Depressed Parents: 30 Years Later
Authors: Myrna M. Weissman, Ph.D., Priya Wickramaratne, Ph.D., Marc J. Gameroff, Ph.D., Virginia Warner, Dr.P.H., Daniel Pilowsky, M.D., M.P.H., Rajni Gathibandhe Kohad, M.D, M.P.H., Helena Verdeli, Ph.D., Jamie Skipper, M.A., Ardesheer Talati, Ph.D.
Affiliations: From the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York (M.M.W., P.W., M.J.G., V.W., D.P., A.T.); the Mailman School of Public Health, Columbia University, New York (M.M.W., P.W., D.P.); the Division of Epidemiology, New York State Psychiatric Institute, New York (M.M.W., P.W., M.J.G., V.W., D.P., R.G.K., H.V., J.S., A.T.); and Teachers College, Columbia University, New York (H.V.).
Disclosures: Dr. Weissman has received funding from the National Institute on Drug Abuse, NARSAD, NIMH, the Sackler Foundation, and the Templeton Foundation; she also receives royalties from American Psychiatric Association Publishing, Multihealth Systems, Perseus Press, and Oxford University Press. Dr. Verdeli has received honoraria for psychotherapy training (Navy mental health staff and residents, Navy Medical Center Portsmouth; Fordham Institute for Humanitarian Studies [Ethiopia]; and StrongMinds [NGO, Uganda]) and for serving as keynote speaker at the Annual Meeting of the Society for Psychotherapy in Primary Care, University of Bologna, 2014; she has served as reviewer of psychotherapy supervision procedures for the World Bank Manual (Johns Hopkins University Press); she has received research funding from the International Medical Corps (NGO), as well as from Grand Challenges Canada; and she serves as Associate Editor of Global Mental Health. All other authors report no financial relationships with commercial interests.
Discussion of unapproved or investigational use of products*: No.
*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.
Robert Freedman, M.D. (Editor-in-Chief, AJP); Susan K. Schultz, M.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP) ; Michael A. Pogachar (Online Content Manager, Journals).
Dr. Schultz has received research support from the Alzheimer’s Disease Cooperative Study for projects conducted in partnership with Toyama Chemical Company and in partnership with Eli Lilly and Company. Dr. Freedman, Mr. Roy, and Mr. Pogachar report no financial relationships with commercial interests.
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