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AJP CME: June 2016 - Effect of Hippocampal and Amygdala Connectivity on the Relationship Between Preschool Poverty and School-Age Depression

Activity Type:

  • Journal CME

Release Date: 6/1/2016

Expiration Date: 5/31/2018

  • AMA PRA Category 1 Physician: 1
  • Participation: 1

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Objective: In this study, the authors tested the hypothesis that poverty experienced in early childhood, as measured by income-to-needs ratio, has an impact on functional brain connectivity at school age, which in turn mediates influences on child negative mood/depression.

Method: Participants were from a prospective longitudinal study of emotion development. Preschoolers 3–5 years of age were originally ascertained from primary care and day care sites in the St. Louis area and then underwent annual behavioral assessments for up to 12 years. Healthy preschoolers and those with a history of depression symptoms underwent neuroimaging at school age. Using functional MRI, the authors examined whole brain resting-state functional connectivity with the left and right hippocampus and amygdala.

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Educational Objective

The participant will recognize relationships between aspects of brain connectivity, preschool poverty, and school-age depression.

Target Audience

This program is designed for all psychiatrists in clinical practice, residents in Graduate Medical Education programs, medical students interested in psychiatry, and other physicians who wish to advance their current knowledge of clinical medicine.

Estimated Time to Complete

Duration: 1 hour
Begin Date: June 1, 2016
End Date: May 31, 2018

How to Earn Credit

In order to earn CME credit, subscribers should read through the material presented in the article. After reading the article, complete the course online at and submit your evaluation and study hours (up to 1 AMA PRA Category 1 Credit™).


The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The APA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Faculty and Planner Disclosures

Title: Effect of Hippocampal and Amygdala Connectivity on the Relationship Between Preschool Poverty and School-Age Depression

Authors: Deanna Barch, Ph.D., David Pagliaccio, Ph.D., Andy Belden, Ph.D., Michael P. Harms, Ph.D., Michael Gaffrey, Chad M. Sylvester, M.D., Ph.D., Rebecca Tillman, M.S., Joan Luby, M.D.

Affiliations: From the Department of Psychiatry; the Department of Radiology, Mallinckrodt Institute of Radiology; the Department of Psychology; and the Program in Neuroscience, Washington University School of Medicine, St. Louis, Mo. (D.B., D.P., A.B., M.P.H., M.G., C.M.S., R.T., J.L.).

Disclosures: Dr. Barch has served as a consultant for Amgen, Pfizer, Takeda, and Roche and has a contract to analyze imaging data for Pfizer. Dr. Luby has received royalties from Guilford Press. The other authors report no financial relationships with commercial interests.

Discussion of unapproved or investigational use of products*: No.

*APA policy requires disclosure by CME authors of unapproved or investigational use of products discussed in CME programs. Off-label use of medications by individual physicians is permitted and common. Decisions about off-label use can be guided by scientific literature and clinical experience.

Program Planners

Robert Freedman, M.D. (Editor-in-Chief, AJP); Susan K. Schultz, M.D. (Deputy Editor, AJP); Michael D. Roy (Editorial Director, AJP) ; Michael A. Pogachar (Online Content Manager, Journals).

Dr. Schultz has received research support from the Alzheimer’s Disease Cooperative Study for projects conducted in partnership with Toyama Chemical Company and in partnership with Eli Lilly and Company. Dr. Freedman, Mr. Roy, and Mr. Pogachar report no financial relationships with commercial interests.

Hardware/Software Requirements

This internet-based CME activity is best experienced using Internet Explorer 8+, Mozilla Firefox 3+, Safari 4+. This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Adobe Acrobat, Microsoft PowerPoint, and Windows Media Player.

Optimal System Configuration:
Flash Player: Adobe Flash Player 10.1+ 
Browser: Firefox 3+, Internet Explorer 8.0+, Safari 4.0+, or Google Chrome 7.0+ 
Operating System: Windows XP+ or Mac OS X 10.4+ 
Internet Connection: 1 Mbps or higher
Screen Resolution: 1024 x 768 pixels.

Minimum Requirements:
Windows PC:
500-MHz Pentium II; Windows XP or higher; 128 MB RAM; Video Card at least 64MB of video memory; Sound Card at least 16-bit; Macromedia Flash Player 10 or higher, audio playback with speakers for programs with video content; Firefox 1.1+, Internet Explorer 7.0+, Safari 1.0+, Google Chrome, or Opera
Mac OS X 10.3 or higher with latest updates installed; 1.83MHz Intel Core Duo or faster; RAM: 128MB or more; Video Card: at least 64MB of video memory; Sound Card: at least 16-bit

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