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Emerging Biomarkers of Response to Ketamine: Opportunities and Challenges

Available: January 1, 2024 - January 1, 2027


On February 1, 2024, the course will be available for purchase.



(R,S)-ketamine (ketamine) and its enantiomer (S)-ketamine (esketamine) can produce rapid and substantial antidepressant effects. However, individual response to ketamine/esketamine is variable, and there are no well-accepted methods to differentiate persons who are more likely to benefit. Numerous potential peripheral (blood-based) biomarkers are being investigated, but their current utility is unclear. This symposium will discuss the emerging biomarkers for ketamine/esketamine response and also present novel data regarding the antianhedonic effect of ketamine with possible mechanistic pathways. This session will cover off-label use of IV ketamine and the FDA-approved esketamine for TRD. Presenters will be Dr. Gustavo C. Medeiros (Blood-based biomarkers of antidepressant response to ketamine and esketamine), Dr. Balwinder Singh (Metabolomic signatures of ketamine associated remission in treatment-resistant depression) and Dr. Jennifer Vande Voort (antianhedonic effect of ketamine and an in vivo increase in mTOR protein expression as a predictive biomarker for antianhedonic effect).


Recorded webinar, non-interactive, self-paced distance learning activity.

This presentation was recorded at the American Psychiatric Association Annual Meeting 2023. 

Learning Objectives

  • To understand the evidence-base of blood-based biomarkers of antidepressant response to ketamine and esketamine in Treatment-Resistant Depression
  • To understand the evidence-base of metabolomic biomarkers of antidepressant response to racemic ketamine in Treatment-Resistant Depression
  • To review the antianhedonic effect of ketamine and mTOR-dependent protein expression as a potential biomarker

Target Audience


Estimated Time to Complete

Estimated Duration: 90 minutes
Begin Date: January 1, 2024
End Date: January 1, 2027

How to Earn Credit

Participants who wish to earn AMA PRA Category 1 Credit ™ or a certificate of participation may do so by completing all sections of the course including the evaluation. After evaluating the program, course participants will be provided with an opportunity to claim hours of participation and print an official CME certificate (physicians) or certificate of participation (non-physicians) showing the event date and hours earned.

Continuing Education Credit

In support of improving patient care, the American Psychiatric Association is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


The APA designates this enduring activity for a maximum of 1.5 AMA PRA Category 1 Credit ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Faculty and Planner Disclosures

The American Psychiatric Association adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Medical Education. Any individuals in a position to control the content of a CME activity — including faculty, planners, reviewers or others — are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Program Presenters

  • Balwinder Singh, M.D., M.S., Mayo Clinic. Reports no financial relationships with commercial interests.
  • Jennifer L. Vande Voort, M.D., Mayo Clinic. Reports no financial relationships with commercial interests.
  • Gustavo C. Medeiros, M.D., University of Maryland School of Medicine. Reports no financial relationships with commercial interests.
  • Giselli Scaini, Ph.D., McGovern Medical School; UTHealth. Reports no financial relationships with commercial interests.

Program Planners

  • Vishal Madaan, MD, Chief of Education and Deputy Medical Director, APA. Reports no financial relationships with commercial interests.

Accessibility for Participants with Disabilities

The American Psychiatric Association is committed to ensuring accessibility of its website to people with disabilities. If you have trouble accessing any of APA’s online resources, please contact us at 202-559-3900 for assistance.

Technical Requirements

This internet-based CME activity is best experienced using any of the following:

  • The latest and 2nd latest public versions of Google Chrome, Mozilla Firefox, or Safari
  • Internet Explorer 11+

This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Acrobat Reader, Microsoft PowerPoint, and Windows Media Player.

Optimal System Configuration:

  • Browser: Google Chrome (latest and 2nd latest version), Safari (latest and 2nd latest version), Internet Explorer 11.0+, Firefox (latest and 2nd latest version), or Microsoft Edge (latest and 2nd latest version)
  • Operating System: Windows versions 8.1+, Mac OS X 10.5 (Leopard) +, Android (latest and 2nd latest version), or iOS/iPad OS (latest and 2nd latest version)
  • Internet Connection: 1 Mbps or higher

Minimum Requirements:

  • Windows PC: Windows 8.1 or higher; 1 GB (for 32-bit)/2 GB (for 64-bit) or higher RAM; Microsoft DirectX 9 graphics device with WDDM driver; audio playback with speakers for programs with video content
  • Macintosh: Mac OS X 10.5 or higher with latest updates installed; Intel, PowerPC G5, or PowerPC G4 (867MHz or faster) processor; 512 MB or higher RAM; audio playback with speakers for programs with video content

For assistance: Contact for questions about this activity | Contact for technical assistance

Availability: On-Demand
Expires on Jan 01, 2027
Cost: Member: $18.75
Non-Member: $37.50
Medical Student: $18.75
Resident Fellow Member: $18.75
Credit Offered:
1.5 CME Credits
1.5 COP Credits
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