Treatment Resistant Depression from Multiple Perspectives: Does it Exist?-View Presentation

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The panel discussion, led by Dr. Karl Marcy from OM1, explores the complex topic of treatment-resistant depression (TRD) and its existence from multiple perspectives. The conversation involves a deep dive into various definitions of TRD, their applications, and implications for diagnosis and treatment. Three different definitions are considered: the regulatory definition (failure of two antidepressant treatments within a major depressive episode), a simple data-driven definition using machine learning, and an AI model based on clinician attestation.<br /><br />Dr. Steve Levine emphasizes the importance of precise definitions for regulatory and clinical trials purposes. He highlights the need for new treatments and quick diagnosis against a backdrop of high suicide rates. Dr. Lisa Harding focuses on a clinician's perspective, emphasizing patient care, health disparities, and the chronic nature of depression. The discussion notes the lack of urgency among healthcare providers in treating depression as an urgent condition, contrasting it with other medical fields. <br /><br />Dr. Joseph Zbinski discusses the role of AI in identifying TRD, stressing that AI models can identify patterns not easily captured by traditional checklists or current definitions. He points out the need for AI-driven insights to move beyond patterns dictated by available data and to help uncover underdiagnosed patient groups.<br /><br />The panelists also discuss the potential of emerging treatments and their ability to shape the future of mental health care. They recognize the challenges of implementing novel treatments and managing health disparities. Despite some skepticism on the adequacy of current definitions and overlapping populations of TRD, the panel acknowledges that TRD exists but is potentially misunderstood in its complexity.

Keywords

treatment-resistant depression

TRD

Dr. Karl Marcy

OM1

AI model

machine learning

Dr. Steve Levine

Dr. Lisa Harding

health disparities

Dr. Joseph Zbinski

emerging treatments

mental health care