Role of Endocannabinoids in Early Brain Development and Consequences of Fetal Cannabinoid Exposure-View Presentation

Video Transcription

Video Summary

The session focused on the impact of cannabinoids, specifically THC, on early brain development and the risks associated with prenatal exposure. Dr. Jorge Manzanares presented research showing significant behavioral and cognitive impairments in rodents exposed to high THC levels during gestation, including anxiety, memory deficits, and altered gene expression related to stress and reward pathways. He warned of increased THC potency and the perception of safety due to legalization.<br /><br />Dr. Jamie Lo examined similar impacts using a rhesus macaque model, highlighting THC's effects on placental function, fetal oxygen availability, and neurodevelopment pathways related to autism spectrum disorders. Infant macaques showed increased anxiety and altered brain white matter development, emphasizing the compound's long-term behavioral impacts.<br /><br />Dr. Laura Stroud discussed human studies, indicating increased marijuana use among pregnant people and its association with adverse infant outcomes, including withdrawal-like symptoms and altered cortisol responses. Her research also identified potential biological mechanisms, such as gene expression changes in the placenta affecting fetal stress responses.<br /><br />Overall, the session underscored the persistence of THC's effects across species and the importance of advising against cannabis use during pregnancy to prevent long-term neurodevelopmental impairments. The speakers emphasized a need for clearer public health messaging, addressing misconceptions about cannabis's safety, and a multidisciplinary approach to studying its impacts.

Keywords

cannabinoids

THC

prenatal exposure

brain development

behavioral impairments

cognitive deficits

neurodevelopment

placental function

fetal stress

public health

cannabis safety

pregnancy risks