Lifelong Learning: Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes-View Article

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A systematic review and meta-analysis found that lithium exposure during pregnancy is associated with a higher risk of spontaneous abortion, congenital anomalies, and cardiac anomalies. However, it did not increase the risk of preterm birth or low birth weight. Lithium was effective in preventing postpartum mood episodes. The dosage and serum lithium levels during pregnancy affected fetal and newborn outcomes, with higher dosages being associated with a higher risk of cardiac malformations. The study recommends careful consideration of the benefits and risks of using lithium during pregnancy on a case-by-case basis, with close monitoring of lithium levels.

Keywords

lithium exposure

pregnancy

spontaneous abortion

congenital anomalies

cardiac anomalies

preterm birth

low birth weight

postpartum mood episodes

dosage

serum lithium levels