Lifelong Learning: Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder-View Article

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Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with repetitive thoughts and behaviors. The neurobiology involves abnormalities in the glutamatergic system and dysfunctions in the CSTC circuit. Serotonin reuptake inhibitors (SRIs) are effective in treating OCD, but the role of serotonin is unclear. Deep brain stimulation (DBS) is an option for severe OCD, but the exact target for the electrode is debated. DBS can change activity and connectivity in the CSTC circuit. Future research using next-generation DBS devices may provide insights into OCD. Understanding the neurobiology is crucial for developing better treatments, especially for treatment-resistant patients.

Keywords

Obsessive-compulsive disorder

OCD

neuropsychiatric disorder

repetitive thoughts

repetitive behaviors

glutamatergic system

CSTC circuit

serotonin reuptake inhibitors

deep brain stimulation

treatment-resistant patients