Lifelong Learning: Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse-View Article

View Article

Pdf Summary

This article reviews the advances in schizophrenia research, with a focus on the role of glutamatergic synapses. It discusses the dopamine hypothesis, the limitations of antipsychotic drugs, and the importance of studying the glutamatergic synapse. Animal models and genetic studies have provided insights into the pathophysiology of schizophrenia. The document also discusses the similarities between schizophrenia and NMDA-receptor-hypofunction mice. It emphasizes that schizophrenia is primarily a disorder of cortical pathology and suggests alternative approaches for treatment. Lastly, it explores the role of genetics, epigenetics, and environmental factors in schizophrenia and concludes with the need for targeted treatments based on a comprehensive understanding of the disorder.

Keywords

schizophrenia research

glutamatergic synapses

dopamine hypothesis

antipsychotic drugs

animal models

genetic studies

pathophysiology

NMDA-receptor-hypofunction

cortical pathology

targeted treatments