Autism Spectrum Disorder: Practical Management and Cutting-Edge Treatments-View Presentation

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Video Summary

The symposium on autism spectrum disorders (ASD) facilitated insightful discussions on comprehensive assessment and new treatment developments. Eric Hollander from Albert Einstein College of Medicine opened the session alongside experts Ron D. Hagerman and Cassara Ferretti. Hollander focused on psychiatric assessments, emphasizing the heterogeneity of ASD symptoms, which range from social deficits and repetitive behaviors to associated issues like ADHD, OCD, epilepsy, and more. He highlighted that cognitive inflexibility is a pervasive challenge and a significant focus for treatment advancements. Traditional treatments like atypical antipsychotics, SSRIs, and anticonvulsants have varying efficacy but carry risk of adverse effects.<br /><br />Emerging therapies are exploring cannabinoids, neuromodulation, and genetic assessments. For instance, CBD and low-dose THC may help with irritability and behavioral issues without the psychoactive effects usually associated with cannabis, although THC usage remains controversial due to concerns about long-term effects like psychosis. Neuromodulation through TMS and other techniques offers another avenue for managing compulsive behaviors. Hollander also noted the need for more precise outcome measures in research to surpass placebo effects, which remain significant.<br /><br />Ron D. Hagerman discussed Fragile X syndrome, highlighting the importance of genetic testing for early diagnosis and treatment. With Fragile X, various targeted treatments are showing promise, from mGluR5 antagonists to the use of metformin. Cassara Ferretti emphasized a strength- and family-based approach, advocating for leveraging ASD's inherent strengths, like enhanced visual processing, while tailoring interventions to individual and family dynamics.<br /><br />Overall, the experts underscored the need for multifaceted treatment strategies tailored to individual profiles, incorporating family involvement, and leveraging potential genetic and environmental influences on autism expression. The symposium provided a robust overview of current challenges and future directions in ASD treatment and assessment.

Keywords

Autism Spectrum Disorders

ASD

Eric Hollander

psychiatric assessments

cognitive inflexibility

atypical antipsychotics

SSRIs

cannabinoids

neuromodulation

genetic assessments

Fragile X syndrome

mGluR5 antagonists

family-based approach

treatment strategies